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Or both the apical and basolateral membranes establish the transmembrane electrochemical gradients that drive Cl uptake across the basolateral membrane and Cl exit across the apical membrane via the cystic fibrosis transmembrane conductance regulator CFTR ; and purinergic-regulated Cl pathways 1, 2 ; . Na appears to be driven into the lumen via the paracellular pathway by the lumen-negative transepithelial electrical gradient. In many epithelia that secrete salt and water, stimulation of secretion is accompanied by activation of basolateral K channels that assist in maintaining the electrochemical gradient driving Cl exit across the apical membrane Figure 1 ; . The nature of the K channel or channels involved in that secretion apparently varies among the types of these epithelia. In a cultured cell line derived from a human colon carcinoma, T84, calcium-activated K channels are upregulated when secretion is stimulated and inhibition or further stimulation of those channels inhibit or stimulate Cl secretion 3, 4 ; . In some intestinal cells, a cyclic-AMPactivated K channel may play a similar role 5.
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